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Silanes and Siloxanes for Sythetics and Pharmaceuticals |
The field of organosilicon chemistry has undergone explosive growth in the past thirty years, organosilicon compounds have many applications in organic chemistry, most notably as:
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Derivatization reagents |
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Blocking / Protective agents |
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Intermediates in organic synthesis |
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Reducing agents. |
Silylating agents are reagents that are used to replace the active hydrogen of a chemical species with a silyl group (-Si RR'R"). In general, the replacement of active hydrogens significantly decreases the reactivity of a functional group and dramatically reduces polar interactions such as hydrogen bonding. These replacements can:
(1) Protect a reactive functional group during one or more chemical reactions
(2) Improve the selectivity of a chemical reaction
(3) Improve stability during distillation
(4) Improve solubility in polar and/or non-polar solvents
(5) Increase volatility by reducing or eliminating hydrogen-bonding
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| Hydrosilanes and hydrosiloxanes such as triethylsilanes, triisopropylsilane and 1,1,3,3-tetramethyldisiloxane are highly selective reducing agents for the reduction of carbon-carbon and carbon-heteroatom multiple bonds, as well as carbon-hydroxy and carbon-halogen single bonds. |
Organosilyl Bloking Agents (Protective Agents) are widely used in organic synthesis especially in syntheses of drugs for most of them can be get easily , have a steady property , easy to use and can be get rid off in very mild conditions.
And in most of these cases, Silane Blocking Agent can protect/ deprotect functional groups selectively. It is has become a novel method for improving the process and enhancing the quality of the products in syntheses of drugs. Silane Blocking Agents (Protective Agents) are widely used in the syntheses including semi-synthesis and total synthesis of prostaglandins, 7-ADCA which is a intermediate of cephalosporin, Taxol which is a new anticance drug and Acylovir-a novel antivius drug.
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Trimethylsilyl Blocking Agents |
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Trialkylsilyl Blocking Agents |
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Phenyl-Containing Blocking Agents |
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Specialty Silicon-Based Blocking Agents |
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Bridging Silicon-Based Blocking Agents |
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